As a member of Company Flow, he honed his production skills alongside DJ Mr. Len and Bigg Jus. His unique style helped Company Flow gain critical, then popular success, culminating in 1997 with Funcrusher Plus. Eventual differences between the group & label Rawkus, lead to El-P & Len leaving the label in 2000.
El-P then started his own record label, Definitive Jux. Of the many albums he has helped produce (most on Definitive Jux), the most influential and successful has been Cannibal Ox's album, The Cold Vein (2001). In 2002 he released his debut album, Fantastic Damage, which received critical acclaim. His follow-up, I'll Sleep When You're Dead, hit stores in March of 2007. It featured a wide range of artists, including The Mars Volta, Trent Reznor of Nine Inch Nails, and Cat Power. El-P has also contributed productions and guest raps to albums by DJ Krush, Aesop Rock, Murs, Cage, Mr. Lif, Prefuse 73, Del the Funky Homosapien, Mike Ladd, The High and Mighty, Aceyalone, and Alec Empire on the first Handsome Boy Modeling School album.
In 2012, El-P released his 3rd solo album, Cancer 4 Cure, on Fat Possum Records. The album was released to general acclaim, aggregating a score of 84 out of 100 on Metacritic.